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SKU: 1191APC

Human Ovarian Fibroblasts

Primary Cells > Reproductive System Cells

Product Type: Female Reproductive Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Ovary

$1,249.00
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Cell Name: Human Ovarian Fibroblasts

  • Description
    Human Ovarian Fibroblasts are primary cells isolated from healthy human ovarian tissue, typically utilized at early passages. These fibroblasts exhibit a spindle-shaped morphology and adhere to culture flasks in a monolayer. They play a pivotal role in maintaining ovarian tissue homeostasis by synthesizing extracellular matrix components and facilitating wound healing processes. In the presence of ovarian cancer cells, these fibroblasts undergo significant structural and biochemical changes, becoming cancer-associated fibroblasts (CAFs). This transformation leads to the secretion of various peptides, including growth factors, chemokines, collagens, and matrix-modifying enzymes, fostering a pro-tumorigenic and immunosuppressive microenvironment that promotes cancer progression and metastasis. Immunophenotypically, they express vimentin and fibroblast-specific protein 1 (FSP1), confirmed via immunocytochemistry. Karyotyping reveals a normal chromosomal profile. These cells are negative for HIV-1, HIV-2, HTLV-I, and HTLV-II, ensuring biosafety. Their unique properties make them invaluable for studying tumor-stroma interactions and the tumor microenvironment.
  • Product Name
    Human Ovarian Fibroblasts
  • Product Type
    Female Reproductive Cells
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Ovarian
  • Disease
    Normal
  • Product Type
    Female Reproductive Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Ovarian Fibroblasts are valuable for their role in promoting cancer progression and invasiveness. They serve as essential in vitro models for studying the pathophysiology of ovarian diseases, providing mechanistic insights. Moreover, these fibroblasts prove to be indispensable tools for establishing in vitro disease models, supporting high-throughput and high-content screening approaches, thereby advancing research and potential therapeutic interventions.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Ovarian Fibroblasts Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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