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SKU: 1077APC

Human Pancreatic Epithelial Cells

Primary Cells > Pancreatic & Islet Cells

Product Type: Pancreatic Cells

Species: Human

Cell Type: Epithelial Cells

Source Organ: Pancreas

$1,249.00
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Cell Name: Human Pancreatic Epithelial Cells

  • Description
    Human Pancreatic Epithelial Cells are primary epithelial cells isolated from healthy adult human pancreatic tissue using enzymatic dissociation and selective adherence techniques. These cells are derived from the exocrine portion of the pancreas and are non-tumorigenic and non-metastatic, making them ideal for in vitro modeling of pancreatic physiology. They display polygonal morphology and grow as adherent monolayers under standard culture conditions. During development, the pancreatic epithelial network differentiates into acinar, ductal, and endocrine cell types, with endocrine progenitors emerging via delamination to form islets of Langerhans. These cells express cytokeratin-19 (CK19), a marker of ductal epithelium, and typically do not express insulin or glucagon, distinguishing them from endocrine cells. Their passage number is generally low to preserve primary characteristics. They are a valuable tool for studying pancreatic development, tissue engineering, and diabetes-related research.
  • Product Name
    Human Pancreatic Epithelial Cells
  • Product Type
    Pancreatic Cells
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Pancreas
  • Disease
    Normal
  • Product Type
    Pancreatic Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Pancreatic Epithelial Cells find valuable applications in scientific research, particularly in investigating the functional impact of oncogenic point mutations in the K-Ras gene, a common driver of pancreatic cancer, which are prevalent in pancreatic cancer and play a crucial role in its early development. These cells serve as an in vitro model to study the transformation of normal pancreatic epithelial cells into cancerous ones. Additionally, they are utilized to identify potential human pancreatic carcinogens by assessing the cellular response to various potential carcinogens.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Pancreatic Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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