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SKU: 1071APC

Human Pancreatic Stellate Cells

Primary Cells > Pancreatic & Islet Cells

Product Type: Pancreatic Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Pancreas

$1,249.00
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Cell Name: Human Pancreatic Stellate Cells

  • Description
    Human Pancreatic Stellate Cells (PSCs) are isolated from human pancreatic tissue and play an important role in desmoplastic reaction associated with pancreas diseases.Morphologically, PSCs display a star-like shape with cytoplasmic processes and exhibit a quiescent or activated phenotype depending on the microenvironment. PSCs are subject to regulation by both autocrine and paracrine factors. They share a multitude of characteristics with their hepatic counterparts. In a resting state, it synthesizes and secretes a small amount of ECM components, such as collagen, fibronectin, laminin, to maintain the normal structure and function of pancreatic tissue. Upon pancreatic injury or inflammation, PSCs become activated, markedly upregulating ECM synthesis and secretion, thereby driving pancreatic fibrosis—a key pathological feature in chronic pancreatitis and pancreatic cancer progression.
  • Product Name
    Human Pancreatic Stellate Cells
  • Product Type
    Pancreatic Cells
  • Species
    Human
  • Cell Type
    Stellate Cell
  • Source Organ
    Pancreas
  • Disease
    Normal
  • Product Type
    Pancreatic Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Pancreatic Stellate Cells (PSCs) can be used as an in vitro cell model to explore the tumor-stroma interaction mechanism in the pancreatic cancer microenvironment and test the efficacy of anti-fibrotic drugs. Its co-culture system with pancreatic cancer cells can simulate the tumor-promoting desmoplastic response, providing an important platform for studying chemotherapy resistance.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Pancreatic Stellate Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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