SKU: 1060APC

Human Periodontal Ligament Fibroblasts

Primary Cells > Oral & Craniofacial Cells

Product Type: Oral Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Oral Cavity

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Cell Name: Human Periodontal Ligament Fibroblasts

  • Description
    Human Periodontal Ligament Fibroblasts (PLFs) are derived from human periodontal ligament tissue. They are the predominant cell type in periodontal ligament and play an important role in the development, function, and regeneration of periodontal connective tissues. PLFs are considered multipotent cells and involved in the synthesis and phagocytosis of collagen and matrix components, secretion of cytokines, as well as osteoclastogenesis. While morphologically resembling gingival fibroblasts, PLFs stand apart in their unique biological responses, matrix protein expression, and elevated alkaline phosphatase activity — a signature of their bone remodeling prowess. PLFs express typical mesenchymal markers such as vimentin, STRO-1, and alkaline phosphatase (ALP).Their unique ability to differentiate into osteoblast-like cells under certain conditions highlights their critical role in maintaining periodontal homeostasis and supporting bone remodeling.
  • Product Name
    Human Periodontal Ligament Fibroblasts
  • Product Type
    Oral Cells
  • Species
    Human
  • Cell Type
    Fibroblast
  • Source Organ
    Periodontal Ligament
  • Disease
    Normal
  • Product Type
    Oral Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Periodontal Ligament Fibroblasts can be used to explore the pathogenesis of periodontitis, drug screening and tissue engineering research. For example, by simulating an inflammatory environment, the effects of cytokines (such as IL-6, TNF-α) on periodontal tissue destruction can be analyzed, or the effects of new biomaterials (such as hydrogels, scaffolds) on cell adhesion and proliferation can be evaluated
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Periodontal Ligament Fibroblasts Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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