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Human RA Peripheral Blood Mononuclear Cells Rheumatoid Arthritis

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human RA Peripheral Blood Mononuclear Cells

  • Description
    Human RA Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of patients with rheumatoid arthritis (RA). Small, round mononuclear cells typical of PBMCs, suspension growth.They contain lymphocytes (T cells, B cells, NK cells) and monocytes. PBMCs play a crucial role in immune regulation. T/B cells mediate adaptive immune responses, and monocytes can differentiate into macrophages or dendritic cells to participate in antigen presentation and inflammatory responses. Elevated activation markers on T cells (e.g., CD69, HLA-DR), increased proinflammatory cytokines such as TNF-α, IL-6, IL-17 expression. In RA, these cells are abnormally activated, leading to the production of autoantibodies (such as anti-CCP antibodies) and increased secretion of proinflammatory cytokines (TNF-α, IL-6, IL-17), driving synovial inflammation and joint destruction .Abnormal activation and autoantibody production (anti-CCP), contributing to RA pathogenesis.
  • Product Name
    Human RA Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Rheumatoid Arthritis
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human RA Peripheral Blood Mononuclear Cells can be used as in vitro cell models to study the mechanisms of autoimmune diseases. They can also be used to screen and identify biomarkers associated with rheumatoid arthritis (RA). In addition, they can be applied to screen and evaluate potential drugs for the treatment of RA.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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