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SKU: 1172APC

Human Renal Glomerular Endothelial Cells

Primary Cells > Kidney & Urinary Cells

Product Type: Renal Cells

Species: Human

Cell Type: Endothelial Cells

Source Organ: Kidney

$1,249.00
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Cell Name: Human Renal Glomerular Endothelial Cells

  • Description
    Human Renal Glomerular Endothelial Cells (HRGEC) are primary cells isolated from human kidney tissue, specifically the glomerular capillaries. These cells are cryopreserved at passage 0 (P0) or passage 1 (P1) and exhibit a cobblestone-like morphology with adherent growth properties. They form the innermost layer of the glomerular filtration barrier and regulate vascular permeability through interactions with podocytes and the basement membrane(1). Functionally, HRGEC express markers such as endothelin-1 and adhesion (e.g., ICAM-1, VCAM-1), which are upregulated during inflammatory or thrombotic processes. Dysfunction of these cells is implicated in diabetic nephropathy, glomerulosclerosis, and albuminuria, due to glycocalyx degradation and altered VE-cadherin expression under pathological conditions. HRGEC exhibit limited proliferative capacity and are not recommended for extended passaging to maintain population purity.
  • Product Name
    Human Renal Glomerular Endothelial Cells
  • Product Type
    Renal Cells
  • Species
    Human
  • Cell Type
    Endothelial
  • Source Organ
    Kidney
  • Disease
    Normal
  • Product Type
    Renal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Renal Glomerular Endothelial Cells (HRGEC) cultured in vitro serve as valuable models for investigating the complex relationship between endothelial cells and renal diseases. These cells are essential tools for establishing in vitro disease models suitable for high-throughput and high-content screening. Studying HRGEC cultures helps researchers gain a comprehensive understanding of glomerular filtration, glomerular diseases, responses to glomerular injuries, and potential for therapeutic interventions. While some responses require in vivo studies, cell cultures allow detailed examination of individual cell behaviors and interactions of specific mediators, facilitating critical insights into renal health and pathology.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Renal Glomerular Endothelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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