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SKU: 1028APC

Human Renal Proximal Tubule Cells

Primary Cells > Kidney & Urinary Cells

Product Type: Renal Cells

Species: Human

Cell Type: Epithelial Cells

Source Organ: Kidney

$1,249.00
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Cell Name: Human Renal Proximal Tubule Cells

  • Description
    Human Renal Proximal Tubule Cells (RPTCs) are primary epithelial cells isolated from the proximal convoluted segment of normal adult human kidneys. In vitro, RPTCs display characteristic epithelial features, such as a spread monolayer, and retain their functional properties under specific culture conditions. They form a polarized monolayer and play essential roles in reabsorbing glucose, amino acids, sodium, and bicarbonate, while secreting waste and xenobiotics. RPTCs express renal markers like γ-glutamyl transpeptidase, alkaline phosphatase, megalin, and transporters (OAT1, OCT2), important for nephrotoxicity studies. They are sensitive to toxins and ischemia, making them a crucial in vitro model for kidney function and disease research. These cells are cryopreserved at early passage.
  • Product Name
    Human Renal Proximal Tubule Cells
  • Product Type
    Renal Cells
  • Species
    Human
  • Cell Type
    Tubular Cell
  • Source Organ
    Kidney
  • Disease
    Normal
  • Product Type
    Renal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Due to their essential role in renal homeostasis, human renal proximal tubule cells provide a valuable tool for studying the biology and pathophysiology of renal tubular cells in vitro. They can used in studies including:[NEW LINE][NEW LINE][NEW LINE]– HRPTCs repair mechanism after injury and their role in the progression of renal fibrosis.[NEW LINE][NEW LINE][NEW LINE]– Intercellular talk between HRPTCs and other cells.[NEW LINE][NEW LINE][NEW LINE]– High-throughput screening of drugs and toxicities.[NEW LINE][NEW LINE][NEW LINE]– Role in renal diseases such as tubular necrosis, tubulointerstitial injury, nephrotoxicity, and renal cancer.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Renal Proximal Tubule Cells Medium Kit
  • Quality Control
    All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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