SKU: 1084APC

Human Retinal Pigment Epithelial Cells

Primary Cells > Eye Cells

Product Type: Ocular Cells

Species: Human

Cell Type: Epithelial Cells

Source Organ: Eye

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Cell Name: Human Retinal Pigment Epithelial Cells

  • Description
    Human Retinal Pigment Epithelial (HRPE) Cells are primary epithelial cells isolated from the retina of healthy human donors via collagenase digestion. These cells form a monolayer of polygonal cells rich in pigment granules and exhibit microvillous projections that interact with photoreceptor outer segments, supporting phagocytic function. HRPE cells maintain the outer blood-retina barrier and are essential for retinal homeostasis, nutrient transport, and visual cycle processing. Dysfunction of HRPE integrity is implicated in retinal degenerative diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt’s disease. HRPE cells express RPE65 and CRALBP, detected by immunocytochemistry or qPCR. Early passage HRPE cells generally maintain a diploid karyotype and are not immortalized. They are tested negative for mycoplasma, bacteria, yeast, fungi, HIV-1, HIV-2, HTLV-I, and HTLV-II, ensuring biosafety compliance.
  • Product Name
    Human Retinal Pigment Epithelial Cells
  • Product Type
    Ocular Cells
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Retina
  • Disease
    Normal
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    By studying Human Retinal Pigment Epithelial (HRPE) Cells, we gain insights into the development, function, and pathobiology of them, enabling us to address conditions such as age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, photoreceptor degeneration, gene expression, and cellular interactions. These investigations provide valuable knowledge for improving diagnosis, understanding disease mechanisms, and developing effective therapeutic strategies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Retinal Pigment Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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