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Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells

  • Description
    Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells (PBMCs) are derived from the peripheral blood of patients with sickle cell anemia (SCA).Peripheral blood from sickle cell anemia patients. Typical mononuclear cells, small and round, suspension growth.They are isolated by density gradient centrifugation and mainly contain lymphocytes (T cells, B cells, NK cells) and monocytes.Altered cytokine profiles with increased proinflammatory cytokines like TNF-α, IL-1β, IL-6; possible oxidative stress markers elevated Under the continuous influence of pathological factors such as chronic hemolysis, PBMCs in SCA patients show obvious functional abnormalities such as dysregulated cytokine secretion, which may in turn affect multiple physiological processes such as immune regulation.Chronic hemolysis and inflammatory environment drive functional dysregulation of PBMCs, contributing to immune dysregulation in SCA.
  • Product Name
    Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Sickle Cell Anemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells can be used to study immune dysfunction mechanisms in SCA. They can also be used to study SCA-related signaling pathways and molecular targets in PBMCs, which will help develop therapeutic drugs targeting specific targets and improve the accuracy and effectiveness of treatment.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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