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Human Sjogren Syndrome Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Sjogren Syndrome Peripheral Blood Mononuclear Cells

  • Description
    Human Sjogren Syndrome Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with Sjogren Syndrome (SS) and are mainly composed of lymphocytes (T cells, B cells, NK cells), monocytes and dendritic cells. Round mononuclear cells; suspension culture; non-adherent.PBMCs play a core role in the SS pathogenesis, especially the overactivation of B cells leading to the production of autoantibodies (such as anti-Ro/SSA, anti-La/SSB), and the imbalance of T cell subsets promoting inflammatory infiltration of glandular tissue. Autoantibodies (anti-Ro/SSA, anti-La/SSB) production by B cells; elevated IFN-γ secretion; altered T cell subset ratios (Th1/Th2 imbalance)In addition, abnormal cytokine secretion of PBMCs (such as IFN-γ) exacerbates the autoimmune response.PBMCs contribute to glandular inflammation and tissue damage through autoimmune mechanisms and cytokine dysregulation.
  • Product Name
    Human Sjogren Syndrome Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Sjogren Syndrome
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Sjogren Syndrome Peripheral Blood Mononuclear Cells can be utilized to investigate the pathological mechanisms underlying Sjogren Syndrome-related diseases, facilitating the exploration of disease biomarkers and targeted therapeutic strategies. Additionally, they serve as a valuable model for evaluating the immunomodulatory effects of targeted therapies on abnormal immune responses in PBMCs.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen

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