SKU: 372BIC

Human SLE Peripheral Blood Mononuclear Cells Systemic Lupus Erythematosus

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

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Cell Name: Human SLE Peripheral Blood Mononuclear Cells

  • Description
    Human SLE Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with systemic lupus erythematosus (a systemic autoimmune disease), including lymphocytes (T cells, B cells, NK cells), monocytes and dendritic cells, Typical mononuclear morphology with small to medium round cells; suspension growth[1-2].Peripheral blood from systemic lupus erythematosus (SLE) patients PBMCs play a core role in the pathogenesis of SLE. Their functional abnormalities include overactivation of B cells leading to autoantibody secretion, imbalanced T cell regulation, and release of proinflammatory factors (IFN-α, IL-6) [3-4]. These abnormalities are closely related to the typical characteristics of SLE, such as immune complex deposition and multi-organ damage (kidney, skin, joints). Increased expression of activation markers like CD69, CD86 on B and T cells; elevated type I interferon signature genes; high autoantibody (anti-dsDNA) producing B cells.Abnormal immune complex deposition triggers chronic inflammation and multi-organ damage typical of SLE.
  • Product Name
    Human SLE Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Systemic Lupus Erythematosus
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human SLE Peripheral Blood Mononuclear Cells (PBMCs) can be used to study the immunopathogenesis of systemic lupus erythematosus (SLE) and develop novel therapeutic strategies. They can also be applied to investigate disease-specific immune dysregulation, including B-cell hyperactivation, T-cell dysfunction, and aberrant cytokine production.
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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