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SKU: 0983APC

Human Thyroid Microvascular Endothelial Cells

Primary Cells > Endocrine Cells

Product Type: Thyroid Cells

Species: Human

Cell Type: Endothelial Cells

Source Organ: Thyroid

$1,249.00
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Cell Name: Human Thyroid Microvascular Endothelial Cells

  • Description
    Human Thyroid Microvascular Endothelial Cells (HTMVECs) are primary endothelial cells isolated from non-diseased thyroid tissue of donors aged 17–66. They form a cobblestone-like monolayer with contact inhibition. HTMVECs are non-tumorigenic and express factor VIII-related antigen, while negative for thyroglobulin and calcitonin. They are commonly used to study thyroid angiogenesis-related disorders like Graves’ disease. FGFR1, FGF-2, and Tie-2 are expressed, confirmed by immunocytochemistry and RT-PCR, and respond to VEGF and anti-angiogenic signals. Cryopreserved at passages 2–4, they retain viability and function. Karyotype analysis data is not reported, but no evidence of tumorigenicity or chromosomal abnormalities has been observed. Cells are screened and negative for HIV-1, HBV, HCV, mycoplasma, and other human pathogens. These properties make HTMVECs ideal for vascular biology and endocrine research.
  • Product Name
    Human Thyroid Microvascular Endothelial Cells
  • Product Type
    Thyroid Cells
  • Species
    Human
  • Cell Type
    Endothelial
  • Source Organ
    Thyroid
  • Disease
    Normal
  • Product Type
    Thyroid Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Thyroid Microvascular Endothelial Cells are crucial for studying in studying thyroid angiogenesis and its involvement in goitrogenesis. These cells are widely used to explore the intricate cross-talk between endothelial and follicular cells during this process. Moreover, they are commonly serve as models for analyzing changes in growth factors, unveiling the molecular mechanisms underlying neoangiogenesis in human thyroid tumors, including thyroid carcinoma cell lines. These applications advance the understanding of thyroid-related vascular biology and the development of potential therapeutic interventions.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Thyroid Microvascular Endothelial Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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