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Human Ulcerative Colitis Peripheral Blood Mononuclear Cells

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Ulcerative Colitis Peripheral Blood Mononuclear Cells

  • Description
    Human Ulcerative Colitis Peripheral Blood Mononuclear Cells (UC-PBMCs) are isolated from the peripheral blood of patients with ulcerative colitis, mainly including T cells, B cells, NK cells and monocytes. UC-PBMCs play a core role in immune regulation and mediate the chronic inflammatory response of UC. Typical mononuclear cells with round or oval nuclei, suspension growth Among them, Th2 cells and innate immune cells (such as monocytes) are overactivated, leading to increased secretion of proinflammatory factors (IL-6, TNF-α) and damage to the intestinal mucosal barrier [1-3]. Overactivation markers on Th2 cells and monocytes; increased proinflammatory cytokines (IL-6, TNF-α).In addition, defective regulatory T cells (Treg) function may aggravate autoimmune reactions. Defective Treg function contributing to immune dysregulation and chronic inflammation.
  • Product Name
    Human Ulcerative Colitis Peripheral Blood Mononuclear Cells
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Ulcerative Colitis
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Ulcerative Colitis Peripheral Blood Mononuclear Cells can be used as an in vitro cell model to study the molecular mechanism of chronic inflammation of the intestinal mucosa. These cells can also be used as a disease biomarker or drug target screening model to provide a basis for the development of anti-inflammatory therapies (such as JAK inhibitors).
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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