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SKU: 1130APC

Human Valvular Interstitial Cells

Primary Cells > Heart & Vascular Cells

Product Type: Cardiac Cells

Species: Human

Cell Type: Fibroblasts

Source Organ: Heart

$1,249.00
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Cell Name: Human Valvular Interstitial Cells

  • Description
    Human Valvular Interstitial Cells (hVICs) are primary fibroblast-like cells isolated from normal human aortic valve tissue. These cells exhibit fibroblast-like morphology with elongated, spindle-shaped profiles under standard culture conditions. Functionally, hVICs participate in valvular homeostasis, but under pathological stimuli, they contribute to calcific aortic valve disease (CAVD) through osteogenic differentiation, a process marked by upregulated alkaline phosphatase (ALP) and collagen type I expression (1). Inflammatory pathways such as NLRP3 inflammasome activation and TGF-β signaling, further exacerbate extracellular matrix (ECM) stiffening and calcium deposition, both hallmarks of CAVD progression (2). Immunophenotyping confirms their identity through positive staining for vimentin and α-SMA, while remaining negative for endothelial markers such as Factor VIII. hVICs require careful handling, repeated freeze-thaw cycles should be avoided to maintain optimal viability.
  • Product Name
    Human Valvular Interstitial Cells
  • Product Type
    Cardiac Cells
  • Species
    Human
  • Cell Type
    Interstitial Cell
  • Source Organ
    Heart Valve
  • Disease
    Normal
  • Product Type
    Cardiac Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Valvular Interstitial Cells (hVICs) are extensively used as an in vitro model to investigate the pathogenesis of calcific aortic valve disease (CAVD).Their responsiveness to pathological cues, including hyperlipidemia, inflammation, and mechanical stress, makes them ideal for studying osteogenic transdifferentiation, extracellular matrix (ECM) remodeling, and mechanotransduction. These cells are widely utilized in preclinical screening of potential therapeutic candidates aimed at halting or reversing valve calcification. Their ability to recapitulate disease-associated phenotypes, such as calcific nodule formation and α-SMA expression, makes them valuable for studying early-stage valve degeneration and potential intervention points.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Human Valvular Interstitial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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