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SKU: 368BIC

Human Waldenstrom’ s Macroglobunemia Peripheral Blood Mononuclear Cells, Untreated

Blood and Immune Cells & Products > Peripheral Blood Mononuclear Cells (PBMCs)

Product Type: Diseased Human Peripheral Blood Mononuclear Cells

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

$1,249.00
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Cell Name: Human Waldenstrom’ s Macroglobunemia Peripheral Blood Mononuclear Cells, Untreated

  • Description
    Human Waldenstrom’s Macroglobunemia Peripheral Blood Mononuclear Cells, Untreated are derived from the peripheral blood of untreated waldenstrom’s macroglobunemia (WM) patients, separated from whole blood by Ficoll density gradient centrifugation, and enriched with lymphocytes (such as T cells, B cells, NK cells) and monocytes. Mononuclear cells with typical lymphocyte morphology; may include abnormal clonal lymphoplasmacytic B cells with variable morphology Normal PBMCs maintain immune homeostasis through mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antigen presentation, while PBMCs of WM patients can lead to pathological changes such as hyperviscosity, autoimmune hemolytic anemia, cryoglobulinemia, and organ amyloidosis due to abnormal proliferation of clonal B cells (lymphoplasmacytic cells) and excessive secretion of monoclonal IgM.Associated with clinical features such as hyperviscosity syndrome, autoimmune hemolytic anemia, cryoglobulinemia, and amyloidosis due to monoclonal IgM production.
  • Product Name
    Human Waldenstrom’ s Macroglobunemia Peripheral Blood Mononuclear Cells, Untreated
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Species
    Human
  • Cell Type
    Mononuclear Cell
  • Source Organ
    Peripheral Blood
  • Disease
    Waldenstrom’ s Macroglobunemia
  • Product Type
    Diseased Human Peripheral Blood Mononuclear Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Human Waldenstrom’ s Macroglobunemia Peripheral Blood Mononuclear Cells, Untreated can be used as ex vivo models to study the pathogenesis of B-cell lymphoproliferative diseases. These cells can also be used to test the efficacy of targeted drugs such as bruton tyrosine kinase (BTK) inhibitors and anti-CD20 monoclonal antibodies
  • Size/Quantity
    1 vial
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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