SKU: 0822ATC

IGR-1 Human Groin Lymph Node Melanoma Specialized Cells

Tumor Cell Lines > Melanoma Cell Lines

Product Type: Human Melanoma Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Lymphatic System

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Cell Name: IGR-1

Human Melanoma cell line. The IGR-1 cell line has been established from the metastatic melanoma in a growing lymph node. IGR-1 cells carry a heterozygous BRAF V600K mutation, but they are wild type with respect to BRAFV600E.

  • Description
    IGR-1 is a human melanoma cell line derived from the inguinal lymph node metastasis of a 42-year-old male patient. It displays epithelial-like morphology and exhibits adherent growth properties. Genetically, IGR-1 carry key oncogenic mutations in BRAF (p.Val600Lys) and RAC1 (p.Pro29Ser), both of which are implicated in melanoma pathogenesis and tumor progression.
  • Product Name
    IGR-1
  • Product Type
    Human Melanoma Cell Lines
  • Species
    Human
  • Source Organ
    Groin Lymph Node
  • Disease
    Melanoma
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The IGR-1 cell line plays a pivotal role in advancing the understanding of human melanoma biology, particularly in the context of oncogenic signaling, metabolic regulation, and cell proliferation mechanisms. It is widely used to investigate the molecular pathways driven by BRAF and RAC1 mutation, supporting preclinical studies aimed at identifying novel therapeutic targets. Additionally, IGR-1 contributes to crucial insights into melanoma research, researchers could explore drug resistance and evaluate the efficacy of potential therapeutic interventions in melanoma, contributing to the development of more effective treatment strategies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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