SKU: 0261ATC

INS-1 Rat Pancreas Specialized Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Rat Pancreas Cancer Cell Lines

Species: Rattus Norvegicus

Cell Type: Other / Specialized Cells

Source Organ: Pancreas

Delivery and Shipping

Ship on dry ice.

Cell Name: INS-1

Insulinoma (Radiation induced cell immortalization).

Description

INS-1 is a rat insulinoma cell line that was originally isolated from pancreas tissue of the x-ray-induced insulinoma in a 2-year-old male rat. INS-1 exhibits the beta-cell-like morphology and adherent culture properties. These cells express a high level of insulin and are sensitive to glucose fluctuations. The INS-1 cells are heterogeneous, consisting of both mature insulin-positive cells and immature bi-hormonal cells that co-express insulin and glucagon. Therefore, INS-1 is a suitable cell line to investigate pancreatic islet beta-cell function and diabetes.
Product Name

INS-1
Product Type

Rat Pancreas Cancer Cell Lines
Species

Rattus Norvegicus
Cell Type

β Cell
Source Organ

Pancreas
Product Type

Rat Pancreas Cancer Cell Lines
Growth Conditions

37 °C, 5% CO2
Application

The INS-1 cell line, renowned for its stability and preserved differentiation, serves as an ideal model to investigate diverse facets of beta-cell activity. It finds extensive utility in deciphering insulin secretion mechanisms, particularly excelling as a tool to explore glucose-triggered insulin release. Moreover, INS-1 cells offer valuable insights into the expression and regulation of proglucagon-derived peptides within primary islets, unraveling their responses to a range of metabolic stimuli.
Size/Quantity

1 vial
Recommended Medium And Supplement

RPMI 1640 + 10% FBS
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

2

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