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SKU: 0720ATC

JIMT-1 Human Breast Breast Cancer Epithelial Cells

Tumor Cell Lines > Breast Cancer Cell Lines

Product Type: Human Breast Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Breast

$1,249.00
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Cell Name: JIMT-1

JIMT-1 cells are HER2-positive, drug-resistant human breast cancer cells lacking hormone receptors, ideal models for HER2 resistance and targeted therapy.

  • Description
    JIMT-1 is a human breast cancer cell line derived from the pleural effusion of a 62-year-old female patient with ductal breast carcinoma. The cells are of epithelial progenitor cell origin and exhibit HER-2 gene amplification, leading to high expression of HER-2 mRNA and protein. These cells are resistant to HER-2-targeting drugs and lack estrogen and progesterone receptors, making them a valuable model for studying HER-2-related drug resistance. JIMT-1 cells grow as an adherent monolayer in DMEM medium supplemented with 10% fetal bovine serum, with the ability to form xenograft tumors in mice. This cell line does not show any specific viral infections (e.g., HPV, HIV, or EBV), but its HER-2 antibody resistance is a key characteristic.
  • Product Name
    JIMT-1
  • Product Type
    Human Breast Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Breast
  • Disease
    Breast Cancer
  • Product Type
    Human Breast Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    JIMT-1 breast cancer cell line offers crucial roles in cancer research and drug development. It can generate xenograft tumors in mice models, allowing researchers to evaluate drug efficacy and inhibitor effectiveness both in vitro and in vivo. For instance, JIMT-1 cells have been extensively used to test HER-2-targeting drugs and small molecule tyrosine kinase inhibitors designed to block the HER-2 signaling pathway. Additionally, JIMT-1 cells can be utilized for genomic screening to identify key genes involved in cell proliferation and tumor growth. These s make JIMT-1 a valuable tool for understanding breast cancer biology, investigating mechanisms of therapeutic resistance, and developing targeted therapies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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