SKU: 0073ATC

Kasumi-1 Human Peripheral Blood Leukemia Myeloblast Cell Line

Tumor Cell Lines > Leukemia Cell Lines

Product Type: Human Leukemia Cell Lines

Species: Human

Cell Type: Myeloblast

Source Organ: Blood

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Cell Name: Kasumi-1

This is a leukemic cell line with an 8;21 Chromosome translocation. This translocation juxtaposes the AML1 with ETO (or MTG8) gene, giving rise to the fusion gene AML1-ETO (also known as AML1-MTG or RUNX1-CBF2T1).

  • Description
    Kasumi-1 is a human acute myeloid leukemia (AML) cell line established from the peripheral blood of a 7-year-old Japanese male patient with relapsed AML (FAB M2 subtype) following bone marrow transplantation. This suspension-growing cell line exhibits myeloblast-like morphology and carries t(8;21)(q22;q22) translocation. Kasumi-1 cells express myeloid surface makers such as CD34, CD33, CD13, CD15, and HLA-DR. They respond to interleukin-3 (IL-3), IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF), but not to IL-1 or IL-5. The cell line is sensitive to phorbol ester-induced macrophage differentiation and demonstrates tumorigenic potential in xenograft model. These features position Kasumi-1 as a critical model for studying AML pathogenesis and therapeutic interventions targeting fusion oncoproteins.
  • Product Name
    Kasumi-1
  • Product Type
    Human Leukemia Cell Lines
  • Species
    Human
  • Cell Type
    Myeloblast
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Myeloid Leukemia
  • Product Type
    Human Leukemia Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Kasumi-1 cell line serve as a critical model for investigating the molecular and cellular mechanisms nderlying acute myeloid leukemia (AML) with t(8;21) translocation. They are extensively used in research on core-binding factor (CBF) leukemias, particularly for studying dysregulated KIT signaling, which frequently co-occurs with this translocation. Kasumi-1 cells support a wider range of s, including 3D cell culture, immunology and hematopoietic disorder studies, and preclinical drug screening. Furthermore, their well-characterized genetic profile and reliable cytokine responsiveness make them a valuable tool for dissecting AML pathophysiology and testing targeted therapeutic strategies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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