Free delivery over $100 Learn more

30 days return period Learn more
SKU: 0431ATC

KMS-12-BM Human Bone Marrow Immune Cells

Tumor Cell Lines > Myeloma Cell Lines

Product Type: Human Myeloma Cell Lines

Species: Human

Cell Type: Immune Cells

Source Organ: Bone Marrow

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: KMS-12-BM

KMS-12-BM Cell Line is from human; Sex: F; Tissue: hemo-lymphocytic; Morphology: lymphocyte-like; Profile: myeloma, late stage of B-cell differentiation.

  • Description
    KMS-12-BM is a human myeloma cell line derived from the bone marrow of a 64-year-old female with non-secretory multiple myeloma. These lymphocyte-like cells grow in suspension and often form small clusters, useful for studying plasma cell aggregation. Cytogenetic analysis shows a t(11;14)(q13;q32) translocation, associated with cyclin D1 (CCND1) dysregulation. They represent the plasmacytoid B-cell stage and are negative for surface and cytoplasmic immunoglobulins. The cells express CD20, CD38, and PCA-1, and lack EBNA, indicating no EBV involvement. Free from mycoplasma, bacteria, fungi, HIV-1/2, HBV, and HCV, they grow in RPMI-1640 with 10% FBS and maintain high viability under strict quality control. KMS-12-BM serves as a reliable model for plasma cell biology, multiple myeloma pathogenesis, biomarker discovery, and drug screening.
  • Product Name
    KMS-12-BM
  • Product Type
    Human Myeloma Cell Lines
  • Species
    Human
  • Cell Type
    Lymphocyte-like
  • Source Organ
    Bone Marrow
  • Product Type
    Human Myeloma Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    KMS-12-BM cells have emerged as a important model in multiple myeloma and plasma cell biology research. These cells provide a reliable platform for investigating the intricacies of the disease, allowing researchers to delve into its underlying molecular mechanisms. Moreover, KMS-12-BM cells enable investigation to explore the proteome and detect possible biomarkers that could aid in diagnosis and prognosis. They can also be utilized to analyze transcriptomic correlation, serving as a representative model for patient tumors and shedding light on the molecular factors influencing disease progression. Additionally, these cells are critical for in drug screening studies, offering insights into drug sensitivity and supporting the prediction of therapeutic outcomes.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you