SKU: 0417ATC

LP-1 Human Blood Multiple Myeloma Specialized Cells

Tumor Cell Lines > Myeloma Cell Lines

Product Type: Human Myeloma Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Blood

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Cell Name: LP-1

Established from the peripheral blood;Disease: Multiple Myeloma.

  • Description
    LP-1 is an immortalized tumor cell line derived from the peripheral blood of a 56-year-old female patient diagnosed with IgG-lambda multiple myeloma in leukemic transformation. The cell line was established in 1986 . LP-1 cells exhibit characteristics reminiscent of immature plasma cells, including an intermediate membrane phenotype between late B lymphocytes and plasma cells. They secrete IgG-lambda chains and, upon exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA) or pokeweed mitogen (PWM), display surface markers and ultrastructural features typical of mature plasma cells, without affecting their proliferation rate .LP-1 cells are cultured in suspension and exhibit typical lymphoblastoid morphology. They are maintained under standard conditions at 37°C in a humidified atmosphere with 5% CO₂.Cytogenetic analysis reveals that LP-1 harbors the t(4;14)(p16.3;q32) translocation, a hallmark of high-risk myeloma, and exhibits overexpression of the c-myc protooncogene, including transcripts of abnormal sizes. Regarding viral status, LP-1 is confirmed to be Epstein-Barr virus (EBV)-negative.
  • Product Name
    LP-1
  • Product Type
    Human Myeloma Cell Lines
  • Species
    Human
  • Source Organ
    Blood
  • Disease
    Multiple Myeloma
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The LP-1 cell line has important s in research. It  is a useful model for studying B-cell maturation, offering insights into unconventional mechanisms of c-myc activation. Moreover, LP-1 cells have the potential to be utilized in the creation of human hybridomas, making them ideal for producing monoclonal antibody-secreting hybrid cell lines. The unique attributes of LP-1 cells contribute to their importance in advancing our understanding of B-cell development and their practical s in antibody production.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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