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SKU: 0624ATC

LU65 Human Lung Specialized Cells

Tumor Cell Lines > Lung Cancer Cell Lines

Product Type: Human Lung Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Lung

$1,249.00
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Cell Name: LU65

Human cell line with giant cell carcinoma of lung. Lung giant cell carcinoma. Altered size of mRNA for RB gene and no expression of RB product. Morphologically, many floating cells are observed.

  • Description
    LU65 is a human lung carcinoma cell line that was originally isolated from the lung tissue of a 64-year-old Japanese male patient with lung cancer. LU65 exhibits epithelial-like morphology and suspension culture properties. This cell line harbors mutations in key oncogenes and tumor suppressor genes, including EGFR, KRAS, RB1, and TP53.
  • Product Name
    LU65
  • Product Type
    Human Lung Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Lung
  • Product Type
    Human Lung Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    LU65 cells serve as an NSCLC research model with lines like A549 and PC9 to study molecular mechanisms of cancer development and progression, including the role of KRAS and TP53 genes. They investigate drug resistance, particularly KRAS-mutant resistance to therapies like sotorasib, while exploring pathway interplay affecting drug response. These cells identify therapeutic targets through CRISPR-Cas9/drug screens, demonstrating that WEE1 inhibition enhances KRAS-targeted therapy efficacy. Additionally, LU65 enables studies on cell growth/proliferation/survival factors, immunohistochemistry for cellular characterization, and research on colony-stimulating factors in leukocytosis and prostaglandin production.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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