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SKU: 019SSC

M2-10B4 Mouse Bone Fibroblasts Cell Line

Stromal / Support Cell Lines > Bone Marrow Stromal Cell Lines

Product Type: Mouse Bone Marrow Cell Lines

Species: Mouse

Cell Type: Fibroblasts

Source Organ: Bone

$1,249.00
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Cell Name: M2-10B4

  • Description
    M2-10B4 is a bone marrow-derived stromal cell line originally isolated from the hematopoietic tissue of a (C57BL/6J X C3H/HeJ)F1 hybrid mouse. These cells exhibit fibroblast-like morphology, and adhere to surfaces in a monolayer growth pattern. M2-10B4 expresses laminin and collagen IV, while lacking collagen I and Factor VIII expression. Functionally, M2-10B4 cells are capable to effectively sustain myelopoiesis for both human and murine hematopoietic cells during extended culture periods. Additionally, this cell line are also capable to support specific murine stromal cell-dependent pre-B cell lines, making it an excellent tool for in vitro research.
  • Product Name
    M2-10B4
  • Product Type
    Mouse Bone Marrow Cell Lines
  • Species
    Mouse
  • Cell Type
    Fibroblast
  • Source Organ
    Bone
  • Product Type
    Mouse Bone Marrow Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    M2-10B4 cells serve as a robust platform in a range of hematological and virological studies. They are particularly valuable for supporting the in vitro growth of murine cytomegalovirus (MCMV), thus enabling detailed investigations into MCMV pathogenesis. In co-culture systems, these cells provides a physiologically relevant stromal environment for exploring the regulation of hematopoietic stem cells (HSCs), aiding in the study of HSC maintenance, proliferation, and differentiation. Moreover, M2-10B4 is employed in models of osteogenic differentiation, contributing to the understanding of bone marrow stromal cell biology and bone tissue engineering.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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