SKU: 0913ATC

MBT-2 Mouse Bladder Bladder Cancer Fibroblasts Cell Line

Tumor Cell Lines > Bladder Cancer Cell Lines

Product Type: Mouse Bladder Cancer Cell Lines

Species: Mouse

Cell Type: Fibroblasts

Source Organ: Bladder

$1,249.00

Size

1 vial

Care information

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Cell Name: MBT-2

MBT2 Cell Line is from mouse; Strain: C3H; Tissue: bladder; Morphology: fibroblast-like; Profile: bladder carcinoma.

Description

MBT-2 is a murine bladder cancer cell line derived from a transitional cell carcinoma in the urinary bladder of a female C3H/He mouse, likely aged 6–8 weeks. Induced by FANFT, these adherent, spindle-shaped cells show fibroblast-like morphology and rapid growth (~24 h doubling time). MBT-2 is highly tumorigenic and metastatic, frequently spreading to the lungs and lymph nodes in syngeneic mice. The line is polyploid (4N–16N) and lacks p16^INK4a^ expression. MBT-2 cells express epithelial markers like cytokeratin. The cell line harbors a replicating type C retrovirus, impacting immune studies. Its robust tumorigenicity makes MBT-2 a reliable model for bladder cancer therapy and metastasis research.
Product Name

MBT-2
Product Type

Mouse Bladder Cancer Cell Lines
Species

Mouse
Cell Type

Fibroblast-like
Source Organ

Bladder
Disease

Bladder Cancer
Product Type

Mouse Bladder Cancer Cell Lines
Growth Conditions

37 °C, 5% CO2
Application

MBT-2 serves as a powerful tool for researchers to investigate the molecular mechanisms driving bladder cancer progression and metastasis. It can be grown in C3H/He mice to create a syngeneic model to test the efficacy and response to immunotherapy treatments.
Size/Quantity

1 vial
Recommended Medium And Supplement

EMEM + 10% FBS
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

1

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