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SKU: 0714ATC

MDA-MB-453 Human Breast Epithelial Cells

Tumor Cell Lines > Breast Cancer Cell Lines

Product Type: Human Breast Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Breast

$1,249.00
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Cell Name: MDA-MB-453

MDA-MB-453 was derived in 1976 by R. Cailleau et al. From an effusion of a 48 year old female patient with metastatic carcinoma of the breast, involving the nodes, brain and both pleural and pericardial cavities. The cells overexpress FGF receptors.

  • Description
    MDA-MB-453 is a human breast cancer cell line derived in 1976 from the effusion of a 48-year-old female patient with metastatic carcinoma of the breast. The cancer had spread to the lymph nodes, brain, pleural cavity, and pericardial cavity. MDA-MB-453 carries a deletion mutation in the p53 gene, resulting in the absence of p53 protein, a common alteration in cancers that contributes to uncontrolled growth. The cell line overexpresses fibroblast growth factor (FGF) receptors, making it useful for studying the genetic and receptor expression characteristics of breast cancer. It is commonly used in cancer research and is free of mycoplasma, bacteria, yeast, and fungi.
  • Product Name
    MDA-MB-453
  • Product Type
    Human Breast Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Breast
  • Product Type
    Human Breast Cancer Cell Lines
  • Growth Conditions
    37 °C
  • Application
    MDA-MB-453 cells have diverse s in breast cancer research. These cells are used to examine the anti-proliferative effects of drugs and uncover the molecular mechanisms behind therapeutic efficacy. Additionally, these cells aid in studying tumorigenesis, signaling pathways related to endocrine resistance, and identifying potential markers for breast cancer. By assessing drug responses, investigating tumor-related pathways, and analyzing gene and protein profiles, MDA-MB-453 cells contribute to understanding breast cancer biology and advancing targeted therapies. Their versatility makes them valuable tools in research aiming to improve treatment outcomes for breast cancer patients.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    L-15 Medium + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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