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SKU: 0657ATC

MKN-28 Human Stomach Specialized Cells

Tumor Cell Lines > Gastric Cancer Cell Lines

Product Type: Human Gastric Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Stomach

$1,249.00
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Cell Name: MKN-28

Mycoplasma-eliminated cells by MC-210Tumorigenecity: Isoenzyme: Histopathology: adenocarcinoma, tubularSubculture: Split ratio: Media change: Reverse transcritase: Production.

  • Description
    MKN-28 is a human gastric tumor cell line originally derived from the metastatic lymph node of a 70-year-old Japanese male patient with well-differentiated adenocarcinoma of the stomach. The cell line displays morphological features of intestinal differentiation, such as cell polarity and microvilli with core filaments both in vitro and in nude mice. MKN-28 is known to carry mutations in the p53 gene (I251L) and the APC tumor suppressor gene, and it exhibits silenced CD44 expression, as well as reduced or absent E-cadherin and β-catenin expression, contributing to its malignant phenotype. MKN-28 has a hypotriploid karyotype and has been reported as cross-contaminated with MKN74, and is thus referred to as MKN-28/74 in current research. The line is tumorigenic but not known to be metastatic.
  • Product Name
    MKN-28
  • Product Type
    Human Gastric Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Stomach
  • Product Type
    Human Gastric Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The MKN-28 cell line holds significant s in various areas of research related to human gastric cancer. It is widely used to study gene therapy approaches using exogenous p53, aiming to develop potential treatments for gastric cancer. Additionally, this cell line serves as a valuable model to examine the mechanisms of proliferation and invasion in gastric cancer cells. Moreover, MKN-28 is used to detect microsatellite instability, providing crucial information for making informed therapeutic decisions in the context of gastric cancer treatment strategies.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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