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SKU: 0493APC

Mouse Epididymal Epithelial Cells

Primary Cells > Reproductive System Cells

Product Type: Epididymal Cells

Species: Mouse

Cell Type: Epithelial Cells

Source Organ: Epididymis

$1,249.00
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Cell Name: Mouse Epididymal Epithelial Cells

  • Description
    Mouse Epididymal Epithelial Cells (MEECs) are primary epithelial cells isolated from the caput region of adult mouse epididymis using enzymatic digestion and selective culture conditions. These cells maintain a polarized pseudostratified morphology, express tight junction proteins (e.g., claudin‑1, occludin) and transporters such as monocarboxylate transporter 1 (MCT1), facilitating luminal acidification and nutrient exchange. MEECs also possess primary cilia that detect fluid shear stress and initiate intracellular calcium signaling and cytoskeletal remodeling. Furthermore, MEECs express pattern recognition receptors (PRRs) including Toll‑like receptor 3 (TLR3), triggering type I interferon, tumor necrosis factor‑α (TNF‑α), and monocyte chemoattractant protein‑1 (MCP‑1) secretion upon viral mimic stimulation. Therefore, MEECs provide a reliable in vitro model for studying barrier integrity, mechanosensing, innate immunity, and sperm–epithelial interactions.
  • Product Name
    Mouse Epididymal Epithelial Cells
  • Product Type
    Epididymal Cells
  • Species
    Mouse
  • Cell Type
    Epithelial Cell
  • Source Organ
    Epididymis
  • Disease
    Normal
  • Product Type
    Epididymal Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    MEECs are utilized to assess epithelial barrier function and transporter-mediated nutrient uptake, notably MCT1-dependent short-chain fatty acid absorption under physiological conditions. They serve as models for mechanotransduction studies—shear stress on primary cilia induces calcium influx and cytoskeletal remodeling. MEECs are also used in innate immunity assays: TLR3 activation by polyinosinic-polycytidylic acid (poly(I:C)) induces type I interferon and proinflammatory cytokine release, modeling antiviral responses in epididymal epithelium. Additionally, MEECs support investigations into epithelial–sperm crosstalk and segment-specific cellular functions through transcriptomic profiling.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Mouse Epididymal Epithelial Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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