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SKU: 0610APC

Mouse Hepatic Stellate Cells

Primary Cells > Liver & Biliary Cells

Product Type: Mouse Primary Cells

Species: Mouse

Cell Type: Fibroblasts

Source Organ: Liver

$1,249.00
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Cell Name: Mouse Hepatic Stellate Cells

  • Description
    Mouse Hepatic Stellate Cells (MHSCs) are primary mesenchymal cells isolated from mouse liver tissue. Primary MHSCs demonstrate limited proliferative capacity and cryopreserved immediately after isolation. These cells reside in the perisinusoidal space of Disse and account for 5–8% of hepatic cells. These cells derived from bone marrow precursors and store up to 80% of the total body vitamin A. Upon liver injury or stress, MHSCs transition into activated myofibroblasts, characterized by increased proliferation and extracellular matrix (ECM) secretion, driving fibrotic responses in conditions like non-alcoholic steatohepatitis and toxin-induced cirrhosis. Primary MHSCs retain physiological vitamin A storage and ECM remodeling functions, making them ideal for modeling early fibrotic pathways.
  • Product Name
    Mouse Hepatic Stellate Cells
  • Product Type
    Mouse Primary Cells
  • Species
    Mouse
  • Cell Type
    Stellate Cell
  • Source Organ
    Liver
  • Disease
    Normal
  • Product Type
    Mouse Primary Cells
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    Mouse Hepatic Stellate Cells offer a robust model system for delving into various facets of liver metabolism and pathophysiology. Their application spans diverse cell-based assays, including toxicity assessment, drug screening, and metabolic studies. They emerge as a crucial resource in the study of liver fibrosis, offering insights that could drive innovative therapeutic strategies for hepatic fibrosis treatment, ultimately aiming to enhance patient outcomes and mitigate the impact of chronic liver injury.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement
    Mouse Hepatic Stellate Cells Medium Kit
  • Quality Control
    All cells test negative for mycoplasma, bacteria, yeast, and fungi.
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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