Free delivery over $100 Learn more

30 days return period Learn more
SKU: 0170ATC

NCI-H322 Human Lung Lung Adenocarcinoma Specialized Cells

Tumor Cell Lines > Lung Cancer Cell Lines

Product Type: Human Lung Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Lung

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: NCI-H322

  • Description
    The NCI-H322 cell line is a human epithelial tumor cell line derived from a 52-year-old Caucasian male with primary bronchioalveolar carcinoma, a non-small cell lung cancer. The cells display epithelial morphology with Clara cell-like ultrastructural characteristics and grow as adherent monolayers under standard conditions (37°C, 5% CO₂). They are tumorigenic in athymic mice. NCI-H322 cells express glutathione-S-transferase, phenol sulfotransferase, and surfactant protein A (SP-A), but lack UDP-glucuronosyltransferase expression. They are ideal for investigating carcinogen metabolism, specifically benzo(a)pyrene (BaP), and their cytotoxic response to BaP suggests involvement of metabolic products like 7,8-diol-BaP. NCI-H322 cells are widely used in lung carcinogenesis, SP-A regulation, and preclinical drug testing targeting tumor suppressor genes and anti-cancer pathways.
  • Product Name
    NCI-H322
  • Product Type
    Human Lung Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Lung
  • Disease
    Lung Adenocarcinoma
  • Product Type
    Human Lung Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The NCI-H322 cell line, due to its deficient glucuronosyltransferase activity, presents an opportunity to investigate the physiological impacts of toxic chemicals that are typically detoxified through glucuronic acid conjugation. These cells serve as valuable test systems for assessing the cytotoxicity and genotoxicity of various substances on the human lung. Moreover, this cell line plays a crucial role in studying genes as tumor suppressors in the development of human lung cancer and assessing the effectiveness of potential drugs or inhibitors for their anti-tumor activity, frequently involving murine models. Overall, NCI-H322 cells have diverse s in toxicology, lung carcinogenesis research, and preclinical drug testing.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 2mM Glutamine + 5-10% FBS
  • Shipping Conditions
    Dry ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    2

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you