Free delivery over $100 Learn more

30 days return period Learn more
SKU: 0945ATC

NCI-H460 Human Specialized Cells

Tumor Cell Lines > Lung Cancer Cell Lines

Product Type: Human Lung Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Other

$1,249.00
Size

Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Cell Name: NCI-H460

NCI-H460 is a large cell lung cancer cell line, derived from the metastatic pleural fluid. Express detectable wild-type p53 mRNA that normal lung tissue does, and has a unique point that do not exhibit significant structural DNA abnormalities. NCI-H1460 is a hypotriploid cell line, with a negative neurofilament triplet protein.

  • Description

    NCI-H460 is a human large cell lung carcinoma cell line established in 1982 from the pleural effusion of a 42-year-old African-American male patient with metastatic disease. NCI-H460 exhibits epithelial-like morphology and adherent growth in monolayer culture. These cells have a hypotriploid karyotype, with a modal chromosome number of 57 (range 53–65), and a doubling time of approximately 23–33 hours. These cells express keratin and vimentin, indicative of both epithelial and mesenchymal phenotypes, but is negative for neurofilament triplet proteins. NCI-H460 demonstrates tumorigenic potential in nude mice models, forming subcutaneous xenografts.
  • Product Name
    NCI-H460
  • Product Type
    Human Lung Cancer Cell Lines
  • Species
    Human
  • Product Type
    Human Lung Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    NCI-H460 serves as an in vitro and in vivo model for studying large cell lung carcinoma and for anticancer drug screening. They are particularly beneficial in 3D cell culture systems, allowing researchers to study tumor growth and evaluate therapeutic responses. The co-expression of epithelial (keratin) and mesenchymal (vimentin) markers makes this cell line valuable for studies on epithelial-mesenchymal transition (EMT) and metastasis progression. Moreover, NCI-H460 contributes to the development of targeted therapies, offering a relevant platform for testing compounds that modulate lung cancer signaling pathways.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

Payment & Security

Payment methods

    Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

    • Visit our support center

      Expert help & advice

    • Check your order status

      Updates & tracking

    • Returns & exchanges

      All you need to know

    • Price-match guarantee

      Our promise to you