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SKU: 0389ATC

NOMO-1 Human Peripheral Blood Leukemia Specialized Cells

Tumor Cell Lines > Leukemia Cell Lines

Product Type: Human Leukemia Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Blood

$1,249.00
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Cell Name: NOMO-1

NOMO-1 cell line is useful for studying the differentiation and maturation of monocytes.

  • Description
    NOMO-1 is a human leukemia cell line established from the peripheral blood of a female patient with acute monocytic leukemia (AML), FAB M5a. These cells exhibit a promonocytic characteristics and can differentiate into macrophage-like cells by 12-o-tetradecanoyl phorbol-13-acetate (TPA) treatment. The cells show increased levels of fibronectin and the secretion of Interleukin-1 (IL-1) α and IL-1 β after TPA stimulation. TPA also induces the secretion of tissue factors from NOMO-1, and this secretion can be inhibited by warfarin. Additionally, plasminogen activator (PA) activity increases during a 17-day culture period. NOMO-1 cells are cultured in RPMI-1640 medium with 10% FBS at 37°C with 5% CO2, and they are cryopreserved at liquid nitrogen temperatures. This cell line is valuable for studying the differentiation and maturation of monocytes, especially in relation to acute monocytic leukemia and macrophage-like differentiation.
  • Product Name
    NOMO-1
  • Product Type
    Human Leukemia Cell Lines
  • Species
    Human
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Monocytic Leukemia
  • Product Type
    Human Leukemia Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    NOMO-1 is a key model for studying the differentiation and maturation of monocytes and for identifying AML-specific antigens for therapeutic targeting. It is used in in drug development and investigating potential signaling pathways. It expresses granulocyte colony-stimulating factor (G-CSF) and responds to exogenous G-CSF. In the NOMO-1 model, it exogenous G-CSF enhances sensitivity to DNA topoisomerase II-targeting drugs and upregulates the expression of transferrin receptor (TfR). Additionally, NOMO-1 serves as a valuable model for studying drug resistance, having demonstrated resistant to pinometostat (EPZ-5676), a selective inhibitor of DOT1L.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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