SKU: 0664ATC

NUGC-4 Human Lymph Node Specialized Cells

Tumor Cell Lines > Gastric Cancer Cell Lines

Product Type: Human Gastric Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Lymphatic System

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Cell Name: NUGC-4

Signet ring cell carcinoma.

  • Description
    NUGC-4 is a human gastric cancer cell line derived from a 35-year-old Japanese female diagnosed with poorly differentiated adenocarcinoma containing signet ring cell carcinoma components in the metastatic paragastric lymph nodes. The cells are characterized by a spherical, epithelial-like morphology and exhibit adhesion properties, although occasional free-floating cells can be observed. They also display anchorage-independent growth, making them suitable for tumorigenicity studies. Typically cultured in PRMI1640 with 10% FBS, they show an average doubling time of 30 hours. The cells have a modal chromosome number of 52–54 in vitro and 53 in vivo. NUGC-4 cells do not express IL-1α mRNA, offering a unique gene expression profile relevant to inflammation and tumor microenvironment studies.
  • Product Name
    NUGC-4
  • Product Type
    Human Gastric Cancer Cell Lines
  • Species
    Human
  • Source Organ
    Lymph Node
  • Product Type
    Human Gastric Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    As a cancer cell line, NUGC-4 is widely used to identify key factors in gastric cancer formation and targets for anti-cancer drugs.Epidermal growth factor (EGF) strongly activates the tyrosine phosphorylation in NUGC-4. Phosphatidylinositol 3-kinase (PI 3-kinase), mainly activated by tyrosine kinases, was precipitated with anti-phosphotyrosine antibodies.Exogenous hepatocyte growth factor can stimulate the proliferation of NUGC-4, and MET tyrosine kinase inhibitors inhibited this proliferation of NUGC-4.Investigation of NUGC-4 and its interactions with growth factors may guide gastric cancer signaling pathways and therapeutic target identification..
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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