SKU: 0466ATC

PLC-PRF-5 Human Liver Epithelial Cells

Tumor Cell Lines > Liver Cancer Cell Lines

Product Type: Human Liver Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Liver

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Ship on dry ice.

Cell Name: PLC-PRF-5

The cells produce HBsAg. At present, there is no evidence that this cell line produces infectious Hepatitis B virus.

  • Description
    PLC-PRF-5 is a human hepatocellular carcinoma (HCC) cell line derived from the liver of a 24-year-old male patient. This epithelial-like cell line exhibits adherent growth properties with a doubling time of approximately 30-40 hours. PLC-PRF-5 harbors integrated hepatitis B virus (HBV) DNA, leading to secretion of HBV surface antigen (HBsAg), though it does not produce infectious viral particles. The cell line demonstrates tumorigenic potential, forming substantial in-situ tumors in murine xenograft models. Key molecular features include overexpression of oncogenes such as c-myc and c-ha-ras, along with frequent TP53 mutations. Its unique combination of HBV antigen production and epithelial hepatoma characteristics makes it particularly valuable for studying virus-associated liver carcinogenesis.
  • Product Name
    PLC-PRF-5
  • Product Type
    Human Liver Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Liver
  • Product Type
    Human Liver Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The PLC-PRF-5 cell line offers a versatile platform for multiple research s. In oncology, it serves as a valuable tool for investigating the molecular mechanisms underlying hepatocellular carcinoma, including pathways driving tumor growth and malignant progression. Furthermore, its ability to produce HBsAg makes it a key model for hepatitis B virus-related liver disease, enabling studies of HBV-associated carcinogenesis and viral-host interactions. Additionally, PLC-PRF-5 contributes to research on sexually transmitted disease with hepatic manifestations and supports efforts to identify biomarkers and therapeutic targets for liver cancer. Its dual relevance to both cancer biology and virology makes PLC-PRF-5 an indispensable tool for advancing translational liver disease research.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    DMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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