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SKU: 0272ATC

PSN1 Human Pancreas Adenocarcinoma Epithelial Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Human Pancreas Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Pancreas

$1,249.00
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Cell Name: PSN1

Human pancreatic adenocarcinoma. The human pancreatic cancer cell line PSN1 was derived from pancreatic adenocarcinoma tissue. After transplantation into nude mice the PSN1 cell line was established from the xenograft.

  • Description
    PSN-1 is a human tumor cell line that was originally isolated from the pancreas of an age-unspecified male patient with pancreatic adenocarcinoma. PSN-1 exhibits epithelial-like morphology and adherent culture properties. It was established through transplantation into nude mice, originating from the xenograft. PSN1 cells maintain the same elevated levels of both c-myc (50-fold) and activated c-Ki-ras (3-6 fold) with a specific mutation (GGT to CGT at codon 12) as found in the original tumor. it is increased c-myc and c-Ki-ras transcripts are present. The cell line shows loss of one p53 allele and a mutation (AAG to CAG at codon 132) in the remaining allele.
  • Product Name
    PSN1
  • Product Type
    Human Pancreas Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Pancreas
  • Disease
    Adenocarcinoma
  • Product Type
    Human Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The PSN-1 cell line finds valuable in the exploration of pancreatic cancer and the development of potential therapeutic interventions, including strategies such as chemoradiation treatment. This cell line’s significance lies in its representation of a cancer cell with intricate genetic alterations involving oncogenes (c-Ki-ras and c-myc) and a tumor suppressor gene (p53). Notably, PSN1 has been utilized for in vitro investigations, such as the study of synthetic acetylhomoagmatine, as well as for assessing the cytotoxicity of irinotecan and topotecan. These s highlight PSN-1’s crucial role in advancing our understanding of pancreatic cancer and aiding the design of targeted treatment approaches.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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