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SKU: 0271ATC

RIN-5F Rat Pancreas Insulinoma Epithelial Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Rat Pancreas Cancer Cell Lines

Species: Rattus Norvegicus

Cell Type: Epithelial Cells

Source Organ: Pancreas

$1,249.00
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Cell Name: RIN-5F

Rat islet cell tumour. RIN-5F is a secondary clone of the rat islet tumour cell line RIN-m. Cloning was performed by limited dilution in RPMI 1640, 10%FBS and 20% conditioned medium. The conditioned medium contained somatotropic hormonees and prolactin being produced by rat pituitary tumour cells GH3.

  • Description
    RIN-5F is a rat pancreatic β-cell tumor cell line derived from the pancreatic islet β-cell tumor tissue of a male NEDH strain rat. This cell line exhibits epithelial-like morphology and adherent growth characteristics. RIN-5F cells robustly express key β-cell markers such as INS-2 (insulin) and GLUT2, along with genes involved in insulin secretion. The cells retain functional responsiveness to insulin signaling pathways. Due to these features, RIN-m5F is widely used in diabetes research, particularly in studies related to oxidative stress, drug protection mechanisms, and genetic modifications.
  • Product Name
    RIN-5F
  • Product Type
    Rat Pancreas Cancer Cell Lines
  • Species
    Rattus Norvegicus
  • Cell Type
    Epithelial
  • Source Organ
    Pancreas
  • Disease
    Insulinoma
  • Product Type
    Rat Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    RIN-5F cells serve as a valuable model for investigating pancreatic islet cell biology. They provide an effective platform for studying the mechanisms governing the synthesis, storage, and secretion of insulin and somatostatin, offering critical insights into endocrine regulation. This cell line’s physiological relevance makes it a powerful tool for research on diabetes, pancreatic islet function and other associated diseases including neuroendocrine tumors.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 2mM Glutamine + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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