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SKU: 0882ATC

Saos-2 Human Bone Epithelial Cells

Tumor Cell Lines > Bone Cancer Cell Lines

Product Type: Human Bone Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Bone

$1,249.00
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Cell Name: Saos-2

Human primary osteogenic sarcoma. Reported to have been derived from an 11 year old female Caucasian.

  • Description
    Saos-2 is a human osteosarcoma cell line derived from the primary tumor of an 11-year-old Caucasian female. These cells exhibit an epithelial-like morphology and grow as an adherent monolayer with a doubling time of approximately 48 hours. Characterized by a hypotriploid karyotype, with a modal chromosome number of 56. Saos-2 demonstrate key osteoblastic properties, including high alkaline phosphatase (ALP) activity and production of bone-specific proteins such as osteocalcin and osteopontin. They also express functional receptors for 1,25-dihydroxyvitamin D3 and parathyroid hormone (PTH), enabling cAMP-mediated responses upon hormonal stimuli. Although derived from a tumor, Saos-2 cells do not show tumorigenicity in immunocompromised mice under standard subcutaneous inoculation. Under osteogenic culture conditions, they can mineralize extracellular matrix, making them valuable for modeling bone microenvironment interactions.
  • Product Name
    Saos-2
  • Product Type
    Human Bone Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial-like
  • Source Organ
    Bone
  • Product Type
    Human Bone Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The Saos-2 cell line has served as a pivotal model of late-stage osteoblastic differentiation, offering unique advantages in bone biology and cancer research. Despite their osteosarcoma origin, Saos-2 cells closely mimic mature human osteoblasts and are characterized by robust alkaline phosphatase (ALP) activity and osteogenic gene expression. Saos-2 cells are particularly useful in studies of bone mineralization, hormonal regulation of osteoblasts, and the interactions between tumor cells and the bone microenvironment. Notably, in comparative analyses, Saos-2 cells exhibited one of the most mature osteoblastic phenotypes among osteosarcoma-derived lines, highlighting its utility in unraveling key molecular events associated with osteogenesis, bone modeling, and skeletal metastasis.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    McCoy’s 5a Medium + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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