SKU: 0354ATC

SF126 Human Brain Fibroblasts Cell Line

Tumor Cell Lines > Nerve Tumor Cell Lines

Product Type: Human Nerve Tumors Cell Lines

Species: Human

Cell Type: Fibroblasts

Source Organ: Brain

Delivery and Shipping

Ship on dry ice.

Cell Name: SF126

Glioblastoma cell line, GFAP-negative.

Description

The SF-126 cell line is a human glioblastoma model originally isolated from a 50-year-old female patient’s astrocytoma tissue in the left frontal lobe. These tumor cells exhibit fibroblast-like morphology with adherent growth properties. Karyotype analysis reveals aneuploidy with chromosome counts ranging from 43 to 47, indicative of genomic instability characteristic of aggressive gliomas . SF-126 lacks glial fibrillary acidic protein (GFAP) expression due to promoter hypermethylation, a feature associated with high-grade astrocytomas. The cells demonstrate tumorigenic potential in xenograft models, with studies showing intracranial tumor formation in immunocompromised mice.
Product Name

SF126
Product Type

Human Nerve Tumors Cell Lines
Species

Human
Cell Type

Fibroblast-like
Source Organ

Brain
Growth Conditions

37 °C, 5% CO2
Application

SF126 cells serve as a valuable tool for studying the cell biology of gliomas and are established as a model for human glioblastoma. Their significance lies in their ability to provide insights into various aspects of cellular physiology and chemosensitivity related to gliomas. They offer a platform to evaluate potential therapies, including radiation, for human gliomas, aiding in the development and testing of novel treatment strategies for this aggressive form of brain cancer.
Size/Quantity

1 vial
Recommended Medium And Supplement

EMEM + 10% FBS
Shipping Conditions

Dry Ice
Storage

Liquid Nitrogen
Biosafety Level

1

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