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SKU: 0301ATC

SH-SY5Y Human Brain Neuroblastoma Epithelial Cells

Tumor Cell Lines > Neuroblastoma Cell Lines

Product Type: Human Bone Marrow Neuroblast Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Brain

$1,249.00
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Cell Name: SH-SY5Y

Tumorigenecity: Isoenzyme: Histopathology: Subculture: Split ratio: Media change: Reverse transcritase: Production.

  • Description
    SH-SY5Y is a human neuroblastoma cell line established from a bone marrow biopsy of a metastatic neuroblastoma patient . This cell line expresses opioids, muscarinic and nerve growth factor receptors . It is an immortalized tumor cell line characterized by continuous proliferation. The cells exhibit a near-triploid karyotype with multiple chromosomal abnormalities commonly observed in cancer cells. SH-SY5Y cells express immature neuronal markers such as Nestin and neurofilament proteins prior to differentiation.These cells exhibit distinct characteristics and differentiation potential. They proliferate continuously as undifferentiated entities, presenting a neuroblast-like morphology and expressing immature neuronal markers. A hallmark of SH-SY5Y cells is their ability to undergo differentiation into neuron-like cells upon exposure to specific agents, such as retinoic acid (RA) and neurotrophins. This differentiation process transforms them morphologically to resemble primary neurons, accompanied by the loss of proliferative capacity and the upregulation of neuron-specific markers.
  • Product Name
    SH-SY5Y
  • Product Type
    Human Bone Marrow Neuroblast Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Brain
  • Disease
    Neuroblastoma
  • Product Type
    Human Bone Marrow Neuroblast Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    SH-SY5Y can be used as in vitro cell models to study the mechanisms of neurodevelopment and neurodegenerative diseases (such as Alzheimer’s disease and Parkinson’s disease). These cells can also be used to evaluate the damaging effects of environmental toxins, heavy metals or nanomaterials on nerve cells.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    EMEM + 15% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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