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SKU: 0570ATC

SKN-3 Human Epithelial Cells

Tumor Cell Lines > Head & Neck Cancer Cell Lines

Product Type: Human Oral Cancer Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Other

$1,249.00
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Cell Name: SKN-3

Established through xenotransplaned tumor in nude mice. Squamous carcinoma.

  • Description
    SKN-3 is a human oral squamous cell carcinoma (OSCC) cell line established via xenotransplantation in mice, derived from a patient with OSCC. This cell line exhibits epithelial-like morphology and adherent growth properties in culture. Genomic profiling identifies a recurrent 2.5-Mb amplification at 19q13.12-13.2, forming homogeneously staining regions and containing 66 transcripts, including the oncogene PAK4, which is markedly overexpressed and drives proliferation through kinase-dependent pathways. SKN-3 demonstrates tumorigenic and metastatic potential in preclinical models, mirroring the aggressive behavior of OSCC .
  • Product Name
    SKN-3
  • Product Type
    Human Oral Cancer Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial-like
  • Product Type
    Human Oral Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The SKN-3 cell line serves as a valuable tool in various s related to oral squamous cell carcinoma (OSCC). It is utilized to study the development and progression of OSCC, providing insights into the tumorigenic mechanisms underlying head and neck cancers. Additionally, researchers use SKN-3 cells to investigate genetic and epigenetic mechanisms that may play pivotal roles in oral tumorigenesis. Moreover, the cell line helps examine the functions of key factors in signaling pathways that promote cancers, making it a promising target for potential therapies against multiple cancer types.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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