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SKU: 0267ATC

T3M-4 Human Specialized Cells

Tumor Cell Lines > Pancreatic Cancer Cell Lines

Product Type: Human Pancreas Cancer Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Other

$1,249.00
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Cell Name: T3M-4

Pancreatic adenocarcinoma producing CEA. K-ras activated. Cell growth is slow. Subculture : once/2 weeks, Medium Renewal : 2 times/week. Chromosome mode: 57-130(50) : /58(4), 59(5), 60810), 61(8), 62(7)/.

  • Description
    T3M-4 is a human pancreatic adenocarcinoma cell line originally derived from a primary pancreatic exocrine tumor and established through xenografting into athymic nude mice. The cells exhibit epithelial morphology and typically grow as an adherent monolayer. Morphologically, T3M-4 cells show epithelial-like features under standard conditions, while co-culture with activated CD4+ T cells induces a more spindle-shaped phenotype. Chromosomal analysis confirms a human hyperdiploid karyotype. Genetically, T3M-4 cells harbor mutations in KRAS (Q61H) and TP53, both commonly implicated in pancreatic cancer. They are known to secrete carcinoembryonic antigen (CEA) both in vitro and in vivo. T3M-4 cells are tumorigenic when transplanted into nude mice and retain their histological characteristics upon serial passage. The line originates from a lymph node metastasis of pancreatic cancer, indicating metastatic potential.
  • Product Name
    T3M-4
  • Product Type
    Human Pancreas Cancer Cell Lines
  • Species
    Human
  • Product Type
    Human Pancreas Cancer Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The T3M-4 cell line offers multiple s in the field of human pancreatic cancer research. Firstly, it can be used to identify the gene profile of human pancreas carcinoma, supporting analysis of oncogene activation as well as aberrant expression and epigenetic changes of genes specific to pancreatic cancer. This aids in understanding the molecular mechanisms underlying the disease. Additionally, T3M-4 cells serve as a useful tool for evaluating the anti-tumor potential of antibodies or drugs, aiding the development of new therapeutic strategies for treating human pancreatic cancer. By assessing the efficacy of different treatments, researchers can advance the search for effective therapies targeting this challenging malignancy.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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