SKU: 092NTC

TCMK-1 Mouse Kidney Epithelial Cells

Non-Tumor Continuous Cell Lines > Kidney & Urinary Cell Lines

Product Type: Mouse Kidney Cell Lines

Species: Mouse-Weanling, Mus Musculus

Cell Type: Epithelial Cells

Source Organ: Kidney

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Cell Name: TCMK-1

The cells ar5e SV40 transformed and are positive for SV40 T-antigen; About 2% of the cells are positive for SV40 viral antigen, but virus is not recoverable; Tested and found negative for ectromelia virus (mousepox)Tumorigenecity: noIsoenzyme: Histopathology: normalSubculture: Split ratio: Media change: Reverse transcritase: negativeProduction.

  • Description
    TCMK-1 is a mouse renal tubular cell line originally derived from the kidney tissue of C3H mouse through SV-40 mediated transformation. These cells exhibits epithelial morphology and grow adherently in culture. TCMK-1 cells express a positive SV40 T-antigen and possess a karyotype model number of 78, with a range from 64 to 157 chromosomes. Most cells contain 2-6 acrocentric chromosomes with secondary constrictions, along with 1-4 biarmed chromosomes per cell. For optimal growth and viability, it is recommended to subculture TCMK-1 cells at a ratio of 1:2 to 1:8 and to refresh the culture medium every 2 to 3 days.
  • Product Name
    TCMK-1
  • Product Type
    Mouse Kidney Cell Lines
  • Species
    Mouse-Weanling, Mus Musculus
  • Cell Type
    Epithelial
  • Source Organ
    Kidney
  • Disease
    Normal
  • Product Type
    Mouse Kidney Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    The TCMK-1 cell line is a valuable model for studying renal pathophysiology, particularly in the context of renal tubular injury. It is widely used to investigate mechanisms of mitochondrial dysfunction, hypoxia/reoxygenation injury, and sepsis-induced acute kidney injury (AKI). They are indtrumental in drug development endeavors aimed at preventing or ameliorating injury and inhibiting renal tubular cell apoptosis. Moreover, TCMK-1 cells play a crucial role in elucidating related regulation pathways involved in renal injury and repair, offering critical insights for the development of novel treatments for AKI and other kidney-related disorders.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    EMEM + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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