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SKU: 093NTC

THLE-2 Human Specialized Cells

Non-Tumor Continuous Cell Lines > Liver Cell Lines

Product Type: Human Liver Cell Lines

Species: Human

Cell Type: Other / Specialized Cells

Source Organ: Other

$1,249.00
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Cell Name: THLE-2

THLE-2 cell line was derived from primary normal liver cells by infection with SV40 large T antigen. These immortalized human liver cells constitute an in vitro model for pharmacotoxicological studies and for the investigation of etiology and pathogenesis of human hepatocellular carcinoma.

  • Description
    THLE-2 cells are an immortalized human liver epithelial cell line established by infecting primary adult liver cells with recombinant SV40 large T antigen. These cells retain epithelial morphology and grow adherently under standard conditions (37 °C, 5% CO₂). They have surpassed 100 population doublings, display a near-diploid karyotype, and are non-tumorigenic in athymic nude mice. They metabolize pro-carcinogens like aflatoxin B1 and N-nitrosodimethylamine, and express detoxifying enzymes, including epoxide hydrolase, NADPH cytochrome P450 reductase, glutathione S-transferases, and others. These properties make THLE-2 ideal for pharmacotoxicological studies, hepatic metabolism, and hepatocellular carcinoma research. Cells are tested negative for mycoplasma, bacteria, fungi, and cryopreserved for high viability.
  • Product Name
    THLE-2
  • Product Type
    Human Liver Cell Lines
  • Species
    Human
  • Product Type
    Human Liver Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    THLE-2 cells can serve as useful models for xenobiotic studies. They are commonly used to study insulin pathways and the regulation of hepatic metabolism. These cells are also employed as an lab-based system for drug toxicity tests, allowing researchers to assess the potential adverse effects of drugs and other substances on liver function. Additionally, THLE-2 cells are valuable tools for exploring liver cancer origins and progression, offering insights into the development and progression of this type of liver cancer.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    2

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