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SKU: 083NTC

THLE-3 Human Liver Epithelial Cells

Non-Tumor Continuous Cell Lines > Liver Cell Lines

Product Type: Human Liver Cell Lines

Species: Human

Cell Type: Epithelial Cells

Source Organ: Liver

$1,249.00
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Cell Name: THLE-3

THLE-3 cell line was derived from primary normal liver cells by infection with SV40 large T antigen. The cells express cytokeratin 18 and albumin in early passage, whereas higher-passage cells in logarithmic-phase growth also express cytokeratin 19.

  • Description
    THLE-3 is a human liver epithelial cell line derived from the left lobe of a healthy adult liver donor. The cells were immortalized using SV40 large T antigen, a viral oncoprotein commonly used to extend the proliferative capacity of primary cells. THLE-3 exhibits features similar to normal adult liver epithelial cells and lacks expression of alpha-fetoprotein. These cells are non-tumorigenic and non-metastatic in athymic nude mice, with a near-diploid karyotype. Functionally, they retain active cytochrome P450 enzymatic pathways and are capable of metabolizing benzo[a]pyrene, N-nitrosodimethylamine, and aflatoxin B1 into DNA-adducting carcinogenic intermediates. THLE-3 cells do not carry any known specific gene mutations or oncogene overexpression, aside from transformation by SV40 large T antigen. It serves as a reliable model for liver toxicology, drug metabolism, and xenobiotic biotransformation studies.
  • Product Name
    THLE-3
  • Product Type
    Human Liver Cell Lines
  • Species
    Human
  • Cell Type
    Epithelial
  • Source Organ
    Liver
  • Disease
    Normal
  • Product Type
    Human Liver Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    THLE-3 cells are used in pharmacotoxicological research and hepatocellular carcinoma pathogenesis studies. As immortalized human liver cells, they offer a reliable in vitro model for liver toxicity and cancer research. Their lies in being a normal cell model for various assays, enabling comparison of responses to compounds between healthy and cancerous liver cells, ensuring that potential effects of substances are specifically targeted towards diseased cells while leaving healthy cells unaffected.
  • Size/Quantity
    1 vial
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    2

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