SKU: 0060ATC

THP-1 Human Peripheral Blood Leukemia Immune Cells

Tumor Cell Lines > Leukemia Cell Lines

Product Type: Human Leukemia Cell Lines

Species: Human

Cell Type: Immune Cells

Source Organ: Blood

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Cell Name: THP-1

The cells are phagocytic (for both latex beads and sensitized erythrocytes) and lack surface and cytoplasmic immunoglobulin. Monocytic differentiation can be induced with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).

  • Description
    TTHP-1 is a human monocytic leukemia-derived tumor cell line originating from the peripheral blood of a 1-year-old male Caucasian patient diagnosed with acute monocytic leukemia. These cells grow in suspension with a round morphology and have typical monocyte features. They possess Fc and C3b receptors, but lack surface or cytoplasmic immunoglobulins. THP-1 cells show positive α-naphthyl butyrate esterase activity inhibited by NaF, and display phagocytic activity for latex beads and opsonized sheep erythrocytes. They can also restore T-lymphocyte response to Concanavalin A (Con A) and produce lysozyme, confirming their monocyte lineage. The cell line’s HLA haplotypes include HLA-A2, -A9, -B5, -DRW1, and -DRW2. Karyotype analysis reveals a near-diploid chromosomal pattern with multiple structural abnormalities, consistent with leukemic origin. THP-1 is often used in NLRP3 inflammasome and NF-κB pathway studies due to high expression of associated components. The cells are tumorigenic, and non-metastatic in immunodeficient mice.
  • Product Name
    THP-1
  • Product Type
    Human Leukemia Cell Lines
  • Species
    Human
  • Cell Type
    Monocyte
  • Source Organ
    Peripheral Blood
  • Disease
    Acute Myeloid Leukemia
  • Product Type
    Human Leukemia Cell Lines
  • Growth Conditions
    37 °C, 5% CO2
  • Application
    THP-1 cells find diverse s due to their unique characteristics. They are widely used for transfection, enabling gene manipulation and functional studies. Additionally, these cells offer valuable insights into monocyte biology and immune responses, providing a reliable model to study monocyte-to-macrophage differentiation. Moreover, THP-1 cells prove invaluable in assessing immune-modulatory effects of compounds in both resting and activated states, making them essential in drug development and immunological research.
  • Size/Quantity
    1 vial
  • Recommended Medium And Supplement

    RPMI 1640 + 10% FBS
  • Shipping Conditions
    Dry Ice
  • Storage
    Liquid Nitrogen
  • Biosafety Level
    1

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